GLP3-R is a research-designated synthetic peptide classified as a triple agonist — meaning it is structurally designed around three receptor-binding motifs — corresponding to the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptor families. Its structure is based on a modified GIP peptide backbone with a C₂₀ fatty diacid lipid chain attached via a linker.

The compound has the molecular formula C₂₂₁H₃₄₂N₄₆O₆₈, a molecular weight of approximately 4,191.7 g/mol, and a CAS number of 2381089-83-2. It is supplied as a white to off-white lyophilized powder that is soluble in water. What distinguishes GLP3-R structurally from dual agonists is the addition of a glucagon receptor-complementary sequence, achieved through specific amino acid substitutions in the peptide chain. The lipid modification serves the same purpose as in other acylated peptides — it enables albumin binding, which extends the molecule’s half-life in solution.

This product is strictly for research purposes only. Not approved for human or animal use.

PubChem Reference: View compound profile on NIH PubChem