Description
Ipamorelin is a synthetic pentapeptide, sequence Aib-His-D-2-Nal-D-Phe-Lys, molecular formula C38H49N9O5, molecular weight 711.86 g/mol, CAS 170851-70-4, first described in the mid-1990s, classified as a growth hormone secretagogue (GHS).
Structurally, Ipamorelin contains two non-standard amino acids: aminoisobutyric acid (Aib) at the N-terminus and D-2-naphthylalanine (D-2-Nal) in the third position. These modifications were specifically engineered to improve receptor selectivity over earlier-generation secretagogues like GHRP-6, which activates the ghrelin/GHS receptor but also produces more pronounced secondary effects on cortisol, prolactin, and appetite. Published pharmacology research has consistently reported that Ipamorelin stimulates GH release with a cleaner secondary hormone profile than these earlier compounds, which is why it’s frequently selected as the ghrelin-receptor component in combination protocols, most notably paired with CJC-1295 in research settings.
In its research-grade form, Ipamorelin appears as a white to off-white lyophilized powder that dissolves readily in water. This product is strictly for research purposes only.
PubChem Reference: View compound profile on NIH PubChem
Key Characteristics
MOLECULAR PROFILE
Formula: C38H49N9O5
Weight: 711.86 g/mol
CAS: 170851-70-4
Structure: Aib-His-D-2-Nal-D-Phe-Lys
PHYSICAL PROPERTIES
Form: White to off-white lyophilized powder
Solubility: Readily dissolves in water
Selectivity: High receptor selectivity
Storage: Keep refrigerated 36‑46 °F (2‑8 °C)
Ipamorelin in Published Research
Ipamorelin’s research value comes largely from its selectivity: published studies comparing it to older secretagogues report GH release with minimal impact on cortisol, prolactin, or appetite, effects that are much more pronounced with GHRP-6 or GHRP-2. This selectivity profile is why it’s become the standard ghrelin-receptor-pathway compound researchers pair with GHRH analogs like CJC-1295 when studying additive, receptor-complementary GH release.
Frequently Asked Questions :
What is Ipamorelin studied for?
Growth hormone secretagogue research, valued for its receptor selectivity compared to earlier GHRPs.
How is it different from GHRP-2 and GHRP-6?
All three are ghrelin-receptor agonists, but Ipamorelin was engineered for greater selectivity, minimizing cortisol, prolactin, and appetite effects seen with the older compounds.
Why is it often paired with CJC-1295?
The two act on different receptors (ghrelin vs. GHRH), providing additive, mechanistically distinct GH-release research value.
How should it be reconstituted and stored?
Bacteriostatic water, refrigerate 2–8°C.
Where can I buy it?
5mg and 10mg kits, HPLC/MS verified.
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