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This research blend pairs Tesamorelin, a stabilized 44-amino-acid analog of growth hormone-releasing hormone (GHRH), with Ipamorelin, a selective five-amino-acid growth hormone secretagogue. The two act through different receptors: Tesamorelin through the GHRH receptor and Ipamorelin through the ghrelin receptor (GHS-R1a). Tesamorelin has the molecular formula C221H366N72O67S and a molecular weight of 5135.9 g/mol; Ipamorelin has the formula C38H49N9O5 and a molecular weight of 711.9 g/mol. Available as an 8 mg blend (6 mg Tesamorelin + 2 mg Ipamorelin) or a 15 mg blend (10 mg Tesamorelin + 5 mg Ipamorelin). Each kit contains 10 vials of white to off-white lyophilized powder, verified by HPLC and mass spectrometry. For laboratory research use only. Not for human or veterinary use.
ℹ️ Note: 1 kit includes 10 vials
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This blend combines one peptide from each of the two main classes used in growth hormone axis research. Tesamorelin is a GHRH analog: the full 44-amino-acid GHRH sequence with a trans-3-hexenoyl group attached to the tyrosine at position 1. That cap blocks the enzyme DPP-IV, which normally breaks GHRH down within minutes. Tesamorelin is the active ingredient of the FDA-approved drug Egrifta. See our standalone Tesamorelin page for full details.
Ipamorelin is a growth hormone secretagogue that mimics ghrelin. It was developed by Novo Nordisk in the 1990s and described in early studies as the first selective secretagogue: it triggered growth hormone release without significantly raising ACTH or cortisol, unlike older peptides such as GHRP-6. Its three non-standard residues, Aib, D-2-naphthylalanine and D-phenylalanine, make it resistant to enzymes. For how it compares with earlier secretagogues, see Ipamorelin vs GHRP-6.
Because GHRH-receptor and ghrelin-receptor signals reach the same pituitary cells through separate routes, researchers often study one agonist from each class together. This blend supplies both from one lot, under one certificate of analysis. The combination itself has not been studied as a single formulation in published research; each peptide’s literature stands on its own.
This product is strictly for research purposes only. Not approved for human or animal use.
| Property | Value |
|---|---|
| Structure | trans-3-hexenoyl-GHRH(1-44)-NH2 |
| Type | 44-amino-acid GHRH analog |
| Molecular formula | C221H366N72O67S |
| Molecular weight | 5135.9 g/mol |
| CAS number | 218949-48-5 (free base); 901758-09-6 (acetate) |
| Receptor | GHRH receptor |
| Property | Value |
|---|---|
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| Type | Pentapeptide (5 amino acids) |
| Molecular formula | C38H49N9O5 |
| Molecular weight | 711.9 g/mol |
| CAS number | 170851-70-4 |
| Receptor | Ghrelin receptor (GHS-R1a) |
| Property | Value |
|---|---|
| Options | 8 mg (6 mg Tesamorelin + 2 mg Ipamorelin); 15 mg (10 mg Tesamorelin + 5 mg Ipamorelin) |
| Kit | 10 vials per kit |
| Form | White to off-white lyophilized powder |
| Testing | HPLC and mass spectrometry on every batch; lot COA available |
| Storage | Refrigerate at 2–8 °C (36–46 °F); −20 °C for long-term storage |
The two components have very different research records. Tesamorelin went through full FDA registration trials before Egrifta was approved in 2010, so its effects on growth hormone release, IGF-1 levels and visceral fat tissue are documented in large, placebo-controlled human studies. Later research has also examined it in liver fat and cognitive studies.
Ipamorelin’s record is mostly preclinical, with some early human work. Studies in rats characterized its selectivity for growth hormone release, and it reached Phase 2 human trials for a gut-motility indication before development stopped. It was never approved. On October 29, 2024, an FDA advisory panel voted 0 to 12, with 1 abstention, against adding Ipamorelin to the compounding pharmacy list. Read why it was left out of the 2026 review in CJC-1295, Ipamorelin and Selank.
For other GHRH analogs used in the same research area, see Sermorelin and Sermorelin vs Tesamorelin.
They act on two different receptors, GHRH and ghrelin, that both lead to growth hormone release. The blend lets researchers study both pathways together from one lot.
Tesamorelin is a 44-amino-acid GHRH analog that works through the GHRH receptor. Ipamorelin is a 5-amino-acid secretagogue that works through the ghrelin receptor (GHS-R1a).
No. Each peptide has its own published research, but the combined blend has not been evaluated as a single formulation.
Tesamorelin is the active ingredient of the FDA-approved drug Egrifta; research-grade Tesamorelin is not that drug. Ipamorelin has never been approved.
An 8 mg option (6 mg Tesamorelin + 2 mg Ipamorelin) and a 15 mg option (10 mg Tesamorelin + 5 mg Ipamorelin). Each kit contains 10 vials, and the lot COA lists both components. See how to read a peptide COA.
Refrigerated at 2–8 °C (36–46 °F), sealed, dry and away from light. For long-term storage, −20 °C. Tesamorelin contains methionine, which oxidizes easily, so keep vials tightly sealed.
| QTY | Buy 1, Buy 12+ and save 20%, Buy 3 and save 10%, Buy 6 and save 15% |
|---|---|
| Weight | 8mg, 12mg |
Mason Callahan –
Blend ratios felt accurate We tested the ratio independently exactly as advertised. The synergy is real. This is now our go-to for GHRP/GHRH combination research.
JT May –
Exactly what I needed
Jessica P –
I was unsure before ordering, but the process was professional and stress-free. Glad I trusted Peptides Vitals
James Richardson –
Smooth ordering process and great communication. Peptides Vitals is highly recommended
Nathan Williams –
Shipping took extra time, but the order was delivered safely and the products were in perfect shape
Lauren Davis –
shipping and premium quality. I strongly recommend ordering from Peptides Vitals
Joshua Green –
Outstanding quality and smooth delivery. I recommend all new customers to try Peptides Vitals
Olivia H –
I had concerns before payment, but everything was transparent
Isabella Flores –
International shipping done right, Shipped to Spain with zero issues. Proper customs documentation and cold chain maintenance. Peptide arrived fully active
Liam Okonkwo –
Consistent from batch to batch Ordered twice over 3 months. Both batches gave nearly identical results in our GH ELISA. That’s rare for blends. Incredible work.
Olivia C. Vance –
Great customer service too Had a quick question about reconstitution volumes. Support replied in 20 minutes. The peptide worked flawlessly in our rat pituitary cell line.
Isaac D. Friedman –
Amazing value for the purity Two potent peptides in one vial at 99%+ purity? Unreal. Our research on pulsatile GH release just got much easier. Thank you
Chloe M. Bennett –
Cleanest blend on the market
We’ve tried three suppliers. This one had the least aggregate formation and most reliable bioactivity in our cell-based GH
Ethan J. Patterson –
Excellent stability data
Kept aliquots at -80°C for 2 months — no degradation by mass spec. The 4.14 average rating is well deserved.
Samantha Brown –
Shipping was lightning fast
Ordered on Monday, arrived Tuesday (US). Peptide looked perfect no clumping. The blend saved us time versus mixing separately.
Marcus T. Holloway –
Perfect for our adipose tissue model
The Tesamorelin component really shone in our lipid metabolism study. Ipamorelin added a nice complementary effect. Highly recommend.
Danielle Wu –
Incredible consistency across vials
Ordered 5 vials for a dose-response study. Each reconstituted cleanly and showed identical activity. This is how research peptides should be
Nathan R. Sterling –
Best blend we’ve tested this year
The synergy between Tesamorelin and Ipamorelin in our GH pulse stimulation assay was outstanding. 99% purity confirmed via HPLC. Will reorder