Description
Thymosin Alpha 1 is a 28-amino-acid peptide, formula C129H215N33O55, weight 3,108.32 g/mol, first isolated in 1977 from Thymosin Fraction 5. CAS 62304-98-7, also known as thymalfasin.
It has a substantial international regulatory history relative to most research peptides. Approved in numerous countries outside the US as Zadaxin, for immune modulation in chronic hepatitis B/C and as a cancer treatment adjuvant, though it has not received FDA approval in the US. This international clinical history has generated a comparatively large body of published research on its immunomodulatory effects, particularly T-cell maturation, dendritic cell function, and cytokine regulation, making it a frequently studied reference compound in immunology research.
Structurally, it’s an acetylated peptide with an acetyl group on its N-terminus, beginning with serine, no cysteine residues, no disulfide bonds. Supplied as a white to off-white lyophilized powder, requires refrigeration when reconstituted. This product is strictly for research purposes only.
PubChem Reference: View compound profile on NIH PubChem
This product is strictly for research purposes only. Not approved for human or animal use.
Key Characteristics
MOLECULAR PROFILE
Formula: C129H215N33O55
Weight: 3108.32 g/mol
CAS: 62304-98-7
Structure: 28 amino acid peptide
PHYSICAL PROPERTIES
Form: White to off-white lyophilized powder
Solubility: Water-soluble
Storage: Requires refrigeration when reconstituted
Also Known As: Thymalfasin
Thymosin Alpha 1 in Published Research
Published research spans several decades, largely building on its clinical use as Zadaxin. Studies have investigated effects on T-cell differentiation, dendritic cell activation, and cytokine profiles, particularly in viral hepatitis and immunocompromised states, plus research as a vaccine adjuvant and in sepsis. Because of its international clinical track record, researchers often reference it as a comparison compound for newer, less-characterized thymic peptides.
Frequently Asked Questions :
What is Thymosin Alpha 1 used for in research?
Immune-modulating effects: T-cell maturation, dendritic cell function, cytokine regulation, building on its clinical use for hepatitis and cancer adjuvant therapy.
Is it FDA-approved?
No, approved in various countries outside the US as Zadaxin; sold here strictly as a research chemical.
What benefits are documented?
Enhanced T-cell maturation, improved dendritic cell function, cytokine modulation, mainly studied in hepatitis, cancer adjuvant, and sepsis research.
How should it be reconstituted and stored?
Bacteriostatic water, refrigerate 2–8°C once dissolved.
Where can I buy it?
5mg and 10mg kits, HPLC/MS verified.
Elena Vasquez –
Good purity, arrived quickly
The 99% purity matched the COA. Used in a cell culture assay consistent results. Would appreciate more detailed reconstitution guidelines
Lauren D –
Strong attention to quality and detail. Very happy with my purchase
Joshua Chloe –
You can tell the company focuses on quality first. Very impressed
Nathan Macmil –
Outstanding company with dependable service. I highly recommend Peptides Vitals.
Amanda Ryan –
Very satisfied customer here. I recommend everyone to order from Peptides Vitals.
Fred Macmil –
My package took longer than expected, but the support team handled it professionally. Delivery was successful
Hartnel smith’s –
Reliable quality products with secure packaging and professional standards.
Jordan Michigan –
satisfied customer here. I recommend everyone to order from Peptides Vitals
Owen Dan –
A courier issue caused some delay, but Peptides Vitals was professional and the package arrived safely
Natalia Popova –
Happy with international delivery
Shipped to Russia with proper documentation. The peptide worked fine in our flow cytometry experiments. Thank you
Megan O’Sullivan –
Nice addition to our thymosin panel
We’re testing multiple thymosins. Alpha-1 from Peptides Vital held up well in parallel assays. No complaints
Christina W. Zhao –
Helpful for our dose-response curve
Used in 5 concentrations — clean peptide peak on HPLC. No degradation issues. Thanks for the free shipping over $200.
Andre Fontaine –
Does the job for basic science
We saw expected biological activity in vitro. Not outstanding, but reliable enough for preliminary data. Shipping to EU took 3 days.
Priya Sharma –
Works as described
Reconstituted easily. Stability under -20°C was fine for 3 months. Would buy again for non-clinical work
Jonathan P. Myers –
Met expectations for research grade
Not the highest rating from me, but still a useful peptide for our T-cell modulation study. Customer service responded within a day.
Rachel K. Ikeda –
Decent batch consistency
Ordered two separate vials. Both showed similar activity in our ELISpot assay. A good option for early-stage research.
Samuel Greer –
We ran a small pilot with Thymosin Alpha-1. Results were promising, though we’ll need to repeat for significance. Shipping was fast and well-packaged
Vanessa C –
Good experience overall I saw the low average rating but decided to try it. Our results were actually quite consistent. Perhaps newer batches improved.