Description
Sermorelin is a synthetic peptide consisting of the first 29 amino acids of GHRH, which in its full form contains 44 amino acids. Its molecular formula is C149H246N44O42S, molecular weight 3,358.04 g/mol, CAS 86168-78-7.
Sermorelin has a well-documented pharmaceutical history. It was FDA-approved in the 1990s under the brand name Geref for diagnosing growth hormone deficiency and studied for therapeutic GH stimulation before the branded product was discontinued from commercial manufacture. That regulatory history means Sermorelin has a comparatively deep base of published human pharmacology data relative to most research peptides, covering effects on pulsatile growth hormone release, IGF-1 levels, and sleep architecture. Because it stimulates the pituitary to release the body’s own growth hormone rather than supplying synthetic HGH directly, it’s often used as a reference compound in research on upstream GH-axis regulation.
The 29-amino-acid fragment represents the shortest GHRH sequence that retains the complete receptor-binding region. The single sulfur atom in its formula comes from a methionine residue at position 27. In research-grade form, Sermorelin appears as a white to off-white lyophilized powder, stable under refrigerated storage. This product is strictly for research purposes only.
PubChem Reference: View compound profile on NIH PubChem
Key Characteristics
MOLECULAR PROFILE
Formula: C149H246N44O42S
Weight: 3,358.04 g/mol
CAS: 86168-78-7
Structure: First 29 amino acids of GHRH
PHYSICAL PROPERTIES
Form: White to off-white lyophilized powder
Solubility: Readily dissolves in water
Stability: Excellent when properly stored
Storage: Keep refrigerated 36‑46 °F (2‑8 °C)
Sermorelin in Published Research
Because Sermorelin was previously an approved pharmaceutical, more human pharmacology data exists for it than most GH-axis research peptides. Studies from its approval era documented dose-dependent increases in growth hormone and IGF-1 pulsatility, plus research into its diagnostic use for identifying GH deficiency in pediatric and adult populations. More recent research has examined effects on sleep architecture and age-related GH decline.
Frequently Asked Questions :
What is Sermorelin used for in research?
Studied for stimulating pulsatile GH release, used as a reference compound in GH-axis, deficiency-diagnostic, and aging research.
What was the approved dose of Geref?
1–2mg subcutaneous range historically; this is drug-label history, not a usage instruction for the research compound.
What benefits are shown in studies?
Increased GH/IGF-1 pulsatility documented in its approval-era trials; sleep and aging research is more recent and ongoing.
How should it be reconstituted and stored?
Bacteriostatic water, refrigerate 2–8°C once dissolved.
Where can I buy it?
5mg and 10mg kits, HPLC/MS verified.
Courtney Lee –
Ordered the Sermorelin kit for a long-term study. Consistency across all 10 vials is impressive. Customer support answered my questions about storage right away. Will definitely reorder
Dr. Henry Wu –
Trustworthy vendor with genuine products. Sermorelin performed flawlessly in our in vivo models. The CAS number (86168-78-7) matched, and the 100% purity was confirmed. Fast shipping to Asia as well
Marcus Webb –
Solid product from a solid vendor. Sermorelin arrived with a clear label, intact vacuum seal, and proper documentation. Free shipping over $200 made this even more affordable for our lab. Highly satisfied
Lauren Mitchell –
Third time ordering Sermorelin from PeptidesVital. Every batch has been identical in quality no clumping, no degradation. The 10-vial kit is a lifesaver for our ongoing experiments. Highly recommend
Brian Torres –
Great value for a 10-vial kit. Sermorelin reconstitutes cleanly no cloudiness or residue. PeptidesVital is becoming my go-to for research peptides. The CAS number matched exactly, and delivery took only 5 days.
Elena Vasquez –
Finally found a reliable Sermorelin source. The kit format is convenient, and each vial holds up well after reconstitution. Our research data has been reproducible and clean. Five stars
Samuel Okafor –
International shipping was smooth the kit arrived in perfect condition. Sermorelin purity is top-tier, and the price per vial for a 10-pack is very reasonable. Excellent experience overall
Dr. Amanda Fields –
Sermorelin arrived as a 10-vial kit, and every vial was perfectly lyophilized. The 100% purity claim held up under our QC tests. Excellent for our growth hormone research studies. Shipping was fast and well-packaged