Selank is a synthetic heptapeptide — a chain of seven amino acids — with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It was first described in the late 1990s. Structurally, Selank is based on tuftsin, a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) that is a fragment of the heavy chain of immunoglobulin G (IgG). The design extended tuftsin by adding a Pro-Gly-Pro tripeptide tail — the same stabilizing extension used in Semax — to slow enzymatic degradation.

The compound has the molecular formula C₃₃H₅₇N₁₁O₉, a molecular weight of 751.87 g/mol, and a CAS number of 129954-34-3. It is also known by the designations TP-7 and Selanc. Selank is supplied as a white to off-white lyophilized powder that is readily soluble in water. The Pro-Gly-Pro motif resists cleavage by prolyl endopeptidases, which gives Selank greater stability in solution compared to the parent tuftsin fragment, which is rapidly degraded.

This product is strictly for research purposes only. Not approved for human or animal use.

PubChem Reference: View compound profile on NIH PubChem