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Semax is a synthetic heptapeptide derived from the 4-10 fragment of adrenocorticotropic hormone (ACTH), with an added Pro-Gly-Pro tripeptide tail for improved stability. It was first described in the late 1980s. The molecule has the sequence Met-Glu-His-Phe-Pro-Gly-Pro, a molecular weight of approximately 826.92 g/mol, and the molecular formula C38H54N12O9. It dissolves readily in water and is supplied as a lyophilized powder. The Pro-Gly-Pro tail is a structural feature designed to resist breakdown by prolyl endopeptidases, giving Semax greater stability than the native ACTH fragment. CAS: 80714-61-0. This product is strictly for research purposes only.
ℹ️ Note: 1 kit includes 10 vials
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Semax is a synthetic heptapeptide — a chain of seven amino acids — with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It was first described in the late 1980s. Structurally, Semax is derived from a fragment of adrenocorticotropic hormone (ACTH), specifically the 4-10 segment, with an added Pro-Gly-Pro tripeptide tail that increases resistance to enzymatic degradation compared to the unmodified ACTH fragment.
The compound has a molecular formula of C37H51N9O10S (free acid form) and a molar mass of approximately 813.93 g/mol (826.92 g/mol as the acetate salt commonly supplied). It is water-soluble and supplied as a white to off-white lyophilized powder. Its CAS registry number is 80714-61-0. The Pro-Gly-Pro extension is a known structural motif used in peptide chemistry to resist cleavage by prolyl endopeptidases, distinguishing it structurally from the native ACTH(4-10) fragment.
This product is strictly for research purposes only. Not approved for human or animal use.
PubChem Reference: View compound profile on NIH PubChem
Formula: C38H54N12O9
Molar Mass: 826.92 g/mol
CAS: 80714-61-0
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Form: White to off-white lyophilized powder
Solubility: Water-soluble
Storage: Requires refrigeration after reconstitution
Stability: Stable in lyophilized form
| Weight | 5mg, 10mg |
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Dr. Anja Schmidt –
International shipping to Germany was surprisingly smooth. Semax purity is outstanding no degradation peptides detected. PeptidesVital has earned a loyal customer for our research team
Kevin Richardson –
Five stars across the board. Semax arrived vacuum-sealed with clear labeling. The CAS number matched, and the peptide performed exactly as expected in our assays. Will be ordering in bulk next time
Dr. Rebecca Liu –
Semax from PeptidesVital is exceptional. The >99% purity is legit our HPLC testing confirmed it. The stability of this heptapeptide with the Pro-Gly-Pro tail makes it ideal for our cognitive research models. Fast shipping, too
Jason Patel –
Ordered Semax for the first time and couldn’t be happier. The lyophilized powder reconstituted perfectly without any haze. Delivery to the US was under a week. Definitely my go-to vendor now
Megan O’Sullivan –
Excellent product. We use Semax regularly in our lab for neuroprotection studies, and PeptidesVital’s batch matches the quality of much more expensive suppliers. Great value and reliable shipping
Sophia Chen –
Very impressed with the quality control. Semax came with a solid vacuum seal and no cracks in the vial. The peptide worked flawlessly in our in vivo models. Highly recommend PeptidesVital for serious researchers
Tyler Brooks –
Third time buying Semax here. Every vial has been consistent: clean, soluble, and potent. Customer service answered my email within hours. Free shipping over $200 is a huge plus for larger orders