Semax

Description

Semax is a synthetic heptapeptide built from the 4 to 10 fragment of adrenocorticotropic hormone (ACTH), with an added Pro-Gly-Pro tripeptide tail for extra stability. Researchers at the Institute of Molecular Genetics in Moscow first developed it in the 1980s, and it has since become one of the most studied nootropic peptides in Russian pharmacology. The molecule has the sequence Met-Glu-His-Phe-Pro-Gly-Pro, a molecular weight of approximately 826.92 g/mol, and the molecular formula C38H54N12O9. It is supplied as a lyophilized powder that dissolves readily in water. CAS: 80714-61-0. This product is strictly for research purposes only.

Key Characteristics :

Molecular Profile:

Formula C38H54N12O9, Molar Mass 826.92 g/mol, CAS 80714-61-0, Sequence Met-Glu-His-Phe-Pro-Gly-Pro

Physical Properties:

Form: white to off-white lyophilized powder. Solubility: water-soluble. Storage: requires refrigeration after reconstitution. Stability: stable in lyophilized form.

Semax in Published Research :

Much of the pharmacological data on Semax comes from Russian clinical and preclinical research. In one randomized, placebo controlled trial involving patients with acute ischemic stroke, researchers administered Semax intranasally within hours of symptom onset and reported measurable improvements in neurological recovery scores compared to standard care alone. Animal studies have similarly reported reduced infarct size and improved functional recovery following ischemic events, along with evidence of antioxidant and anti-inflammatory activity.

Beyond stroke research, Semax has been studied in models of chronic stress and cognitive decline, where it appeared to preserve hippocampal neurogenesis and prevent stress related reductions in BDNF expression. A more recent study published in Acta Naturae examined Semax and a related derivative in a transgenic mouse model of Alzheimer’s disease and reported improved cognitive performance, though this line of research remains preclinical. These findings are cited here for research and educational context only. Peptides Vital does not sell Semax for human use, diagnosis, or treatment of any condition.

Frequently Asked Questions :

What is Semax peptide used for in research?

In published research, Semax has primarily been studied for its effects on neuroprotection, cognitive function, and recovery after ischemic brain injury. It is approved as a clinical treatment for stroke and cognitive disorders in Russia, and is used in laboratory settings elsewhere to study BDNF signaling, neuroplasticity, and stress related changes in brain chemistry.

What dosage of Semax is used in published studies?

Russian clinical trials investigating acute stroke have used total intranasal doses in the range of roughly 9 to 18 milligrams per day, divided across multiple administrations. Preclinical and laboratory studies exploring cognitive endpoints have generally used much smaller, microgram range doses. Peptides Vital does not provide human dosing instructions. These figures are shared for research reference only, and any study protocol should be designed and supervised by the investigator.

What are the reported benefits of Semax in scientific literature?

Published research associates Semax with increased BDNF and NGF expression, modulation of dopamine and serotonin signaling, reduced oxidative stress, and neuroprotective effects during ischemic injury. Most of this evidence comes from Russian clinical trials and animal studies, with a growing but still limited body of Western research.

How should Semax be stored and handled in the lab?

Semax should be kept as a lyophilized powder in a cool, dry place prior to reconstitution, and refrigerated at 2 to 8°C once dissolved in bacteriostatic water. Standard laboratory handling practices, including proper labeling and aliquoting, help preserve peptide stability across freeze thaw cycles.

Where can I buy Semax peptide for research?

Peptides Vital supplies Semax as a research chemical in 5mg and 10mg kits, with each batch verified for purity through HPLC and mass spectrometry. A certificate of analysis is available on request, and the product is sold strictly for laboratory and scientific research.