Description
CJC-1295 (no DAC) is a synthetic 29-amino-acid peptide, also referred to as Modified GRF (1-29) or Mod GRF, a truncated and modified analog of GHRH, which is naturally a 44-amino-acid peptide produced in the hypothalamus. First synthesized in the early 2000s, the “no DAC” designation indicates this version lacks the Drug Affinity Complex, a reactive chemical group used in the longer-acting CJC-1295 variant to bind covalently to serum albumin.
The DAC and no-DAC versions are studied for different research purposes because of their very different half-lives. No-DAC CJC-1295 clears in roughly 30 minutes, similar to native GHRH, which makes it useful for research into acute, pulsatile GH release patterns. The DAC version, by contrast, binds serum albumin for a half-life measured in days, useful for research into sustained GH/IGF-1 elevation. Four amino acid substitutions at positions 2, 8, 15, and 27 of the native GHRH(1-29) sequence replace residues normally vulnerable to enzymatic cleavage by DPP-IV, giving this analog greater stability in solution than the unmodified fragment despite its short functional half-life.
The compound has the molecular formula C152H252N44O42, molecular weight approximately 3,368 g/mol, CAS 446036-97-1. It is supplied as a lyophilized powder, soluble in water. This product is strictly for research purposes only.
PubChem Reference: View compound profile on NIH PubChem
Key Characteristics
MOLECULAR PROFILE
Formula: C152H252N44O42
Weight: ~3,368 g/mol
CAS: 446036-97-1
Structure: 29 amino acids with 4 strategic substitutions
PHYSICAL PROPERTIES
Form: Lyophilized powder
Solubility: Soluble in water
Half-life: Approximately 30 minutes
Storage: Keep refrigerated 36‑46 °F (2‑8 °C)
No-DAC vs. DAC CJC-1295, Why It Matters for Research Design
The choice between DAC and no-DAC versions changes what a study can actually measure. No-DAC’s short half-life preserves the pulsatile pattern of natural GH secretion, which matters for research into the physiological signaling rhythm itself. DAC’s extended half-life instead produces sustained receptor activation, useful for research into cumulative downstream effects like IGF-1 elevation over time, but at the cost of the natural pulse pattern.
Frequently Asked Questions :
What does “no DAC” mean?
This version lacks the Drug Affinity Complex that lets the DAC variant bind serum albumin for an extended, roughly week-long half-life; no-DAC clears in about 30 minutes.
How is this different from CJC-1295/Ipamorelin blend?
This is the standalone GHRH analog; the blend combines it with Ipamorelin, a separate ghrelin-receptor agonist, at a 1:1 ratio.
What’s studied with the no-DAC version specifically?
Its short half-life makes it useful for research into acute, pulsatile GH release rather than sustained elevation.
How should it be reconstituted and stored?
Bacteriostatic water, refrigerate 2–8°C.
Where can I buy it?
5mg and 10mg kits, HPLC/MS verified.
Dr. Matthew S. Hollister –
CJC-1295 noDAC delivered outstanding purity in our GHRH receptor studies. The absence of DAC allowed precise control over pulse kinetics in vitro. Highly reproducible results across three separate orders
Prof. Yuki H. Tanaka –
Perfectly suited for our pulsatile GHRH simulation experiments. CAS 863288-34-0 verified. Lyophilization was excellent — easy reconstitution with sterile water. A reliable staple in our peptide library
Prof. Linda C. Beaumont –
Very clean product with confirmed 100% purity via HPLC. The noDAC version is ideal for acute dosing protocols where continuous activation isn’t desired. Shipping was fast and lyophilized cake was intact
Dr. Kevin T. Olson –
Solid product for growth hormone secretagogue research. No unexpected degradation peaks. The noDAC formulation is clearly distinguishable from CJC-1295 with DAC in our pharmacokinetic assays. Minor delay in tracking info, but product quality made up for it
Dr. Alistair J. Ng –
Excellent batch consistency. Compared to full DAC versions, this analog gave us the short half-life needed for pulsatile signaling experiments. Great value for research use. Will order again
Prof. Raquel M. Fuentes –
Flawless performance in both cell cultures and rodent models. The 100% purity claim held up under our mass spec analysis. One of the cleaner research peptides we’ve sourced this year.