CJC-1295 (no DAC) is a synthetic peptide consisting of 29 amino acids, also referred to as Modified GRF (1-29) or Mod GRF. It is a truncated and modified analog of growth hormone-releasing hormone (GHRH), which is naturally a 44-amino acid peptide produced in the hypothalamus. CJC-1295 was first synthesized in the early 2000s. The “no DAC” designation indicates this version lacks the Drug Affinity Complex — a reactive chemical group used in the longer-acting variant to bind covalently to serum albumin.

The compound has the molecular formula C₁₅₂H₂₅₂N₄₄O₄₂, an approximate molecular weight of 3,368 g/mol, and a CAS number of 446036-97-1. It is supplied as a lyophilized powder that is soluble in water. Four amino acid substitutions at positions 2, 8, 15, and 27 of the native GHRH(1-29) sequence replace residues that are normally vulnerable to enzymatic cleavage by dipeptidyl peptidase-IV (DPP-IV), giving this analog greater stability in solution than the unmodified fragment.

This product is strictly for research purposes only. Not approved for human or animal use.

PubChem Reference: View compound profile on NIH PubChem