Description
GHRP-2 (pralmorelin) is a synthetic hexapeptide, sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2, where D-2-Nal refers to D-2-naphthylalanine, an unnatural amino acid. Molecular formula C45H55N9O6, molecular weight 817.99 g/mol, CAS 158861-67-7. The amidated C-terminus distinguishes it from peptides ending in a free carboxyl group.
GHRP-2 has a notable place in the history of growth hormone secretagogue research: it was developed and characterized as a GHS-R ligand years before that receptor’s natural hormone, ghrelin, was discovered in 1999. That later discovery retroactively explained why GHRP-2 and related synthetic secretagogues worked, they were activating the same receptor pathway ghrelin naturally uses. This makes GHRP-2 both a practical research tool for studying GH secretagogue pharmacology and a historically significant compound in the broader story of ghrelin receptor biology.
GHRP-2 was developed in the early 1990s and is classified as a growth hormone secretagogue and ghrelin receptor agonist. It is supplied as a white to off-white lyophilized powder that dissolves readily in water. This product is strictly for research purposes only.
PubChem Reference: View compound profile on NIH PubChem
Key Characteristics
MOLECULAR PROFILE
Formula: C45H55N9O6
Weight: 817.99 g/mol
CAS: 158861-67-7
Sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
PHYSICAL PROPERTIES
Form: White to off-white lyophilized powder
Solubility: Readily dissolves in water
Stability: Stable when lyophilized
Storage: Keep refrigerated 36‑46 °F (2‑8 °C)
GHRP-2 vs. GHRP-6
GHRP-2 and GHRP-6 are both ghrelin receptor agonists developed around the same era, but they differ in potency and secondary effects. Published pharmacology research generally reports GHRP-2 as a more potent GH secretagogue than GHRP-6, while GHRP-6 is more strongly associated with appetite stimulation, a difference researchers use to select between them depending on whether GH release or appetite effects are the study’s focus.
Frequently Asked Questions :
What is GHRP-2 studied for?
Growth hormone secretagogue research and ghrelin receptor pharmacology, as one of the original compounds characterized against the GHS-R before ghrelin itself was discovered.
How does GHRP-2 compare to GHRP-6?
GHRP-2 is generally reported as more potent for GH release; GHRP-6 is more associated with appetite stimulation.
What is pralmorelin?
GHRP-2’s International Nonproprietary Name (INN), used interchangeably in the pharmacology literature.
How should it be reconstituted and stored?
Bacteriostatic water, refrigerate 2–8°C.
Where can I buy it?
5mg and 10mg kits, HPLC/MS verified.
Dr. Connor J. Reeves –
One of the cleaner GHRP-2 samples we’ve sourced. 99%+ purity confirmed in-house. Ideal for preclinical studies on ghrelin receptor agonism. Fast shipping and well-packaged lyophilized powder
Dr. Rafael S. Mendoza –
Good solid peptide for growth hormone secretagogue research. No unexpected degradation peaks on HPLC. CAS 158861-67-7 confirmed. Minor note the vial was slightly overfilled, but that’s not a complaint, just an observation. Quality is excellent
Prof. Layla T. Ibrahim –
Very consistent quality across multiple vials. The peptide reconstituted easily and remained stable in solution for 48 hours. Would give 5 stars if shipping tracking was more detailed, but the product itself is top-tier.
Dr. Marcus A. Vellinga –
Reliable and potent GHRP-2. Our growth hormone secretion assays showed excellent dose-dependent responses. CAS 158861-67-7 verified by mass spec. Clean peptide with no detectable impurities