Description
Melanotan 1, also known as afamelanotide, is a synthetic analog of alpha-melanocyte-stimulating hormone (alpha-MSH). It is a linear peptide composed of 13 amino acids with the molecular formula C78H111N21O19 and a molecular weight of 1646.85 g/mol. Its CAS registry number is 75921-69-6. The “linear” designation means the amino acid chain is arranged in a straight sequence without any internal ring or bridge structures, in contrast to its cyclic counterpart Melanotan 2.
Melanotan 1 was first synthesized in the 1980s by modifying the natural alpha-MSH sequence to create a more chemically stable version with greater resistance to enzymatic degradation. It is classified as a melanocortin receptor agonist with high selectivity for the MC1R (melanocortin-1 receptor) subtype. The compound is supplied as a white to off-white lyophilized powder that dissolves readily in water.
This product is strictly for research purposes only. Not approved for human or animal use.
PubChem Reference: View compound profile on NIH PubChem
Key Characteristics
MOLECULAR PROFILE
Formula: C78H111N21O19
Weight: 1646.85 g/mol
CAS: 75921-69-6
Structure: Linear 13-amino acid peptide
PHYSICAL PROPERTIES
Form: White to off-white lyophilized powder
Solubility: Readily dissolves in water
Selectivity: High MC1R selectivity
Storage: Keep refrigerated 36‑46 °F (2‑8 °C)





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