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CJC-1295 (no DAC), also called Modified GRF (1-29), is a synthetic 29-amino acid peptide and modified analog of growth hormone-releasing hormone (GHRH). First synthesized in the early 2000s, it replicates the first 29 amino acids of native GHRH with four strategic substitutions at positions 2, 8, 15, and 27 that resist cleavage by dipeptidyl peptidase-IV (DPP-IV). The “no DAC” label means this version lacks the Drug Affinity Complex used in the longer-acting variant. Molecular formula: C152H252N44O42; weight: approximately 3,368 g/mol; CAS: 446036-97-1. Supplied as a lyophilized powder, soluble in water. This product is strictly for research purposes only.
ℹ️ Note: 1 kit includes 10 vials
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CJC-1295 (no DAC) is a synthetic peptide consisting of 29 amino acids, also referred to as Modified GRF (1-29) or Mod GRF. It is a truncated and modified analog of growth hormone-releasing hormone (GHRH), which is naturally a 44-amino acid peptide produced in the hypothalamus. CJC-1295 was first synthesized in the early 2000s. The “no DAC” designation indicates this version lacks the Drug Affinity Complex — a reactive chemical group used in the longer-acting variant to bind covalently to serum albumin.
The compound has the molecular formula C152H252N44O42, an approximate molecular weight of 3,368 g/mol, and a CAS number of 446036-97-1. It is supplied as a lyophilized powder that is soluble in water. Four amino acid substitutions at positions 2, 8, 15, and 27 of the native GHRH(1-29) sequence replace residues that are normally vulnerable to enzymatic cleavage by dipeptidyl peptidase-IV (DPP-IV), giving this analog greater stability in solution than the unmodified fragment.
This product is strictly for research purposes only. Not approved for human or animal use.
PubChem Reference: View compound profile on NIH PubChem
Formula: C152H252N44O42
Weight: ~3,368 g/mol
CAS: 446036-97-1
Structure: 29 amino acids with 4 strategic substitutions
Form: Lyophilized powder
Solubility: Soluble in water
Half-life: Approximately 30 minutes
Storage: Keep refrigerated 36‑46 °F (2‑8 °C)
| Weight | 5mg, 10mg |
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Dr. Matthew S. Hollister –
CJC-1295 noDAC delivered outstanding purity in our GHRH receptor studies. The absence of DAC allowed precise control over pulse kinetics in vitro. Highly reproducible results across three separate orders
Prof. Yuki H. Tanaka –
Perfectly suited for our pulsatile GHRH simulation experiments. CAS 863288-34-0 verified. Lyophilization was excellent — easy reconstitution with sterile water. A reliable staple in our peptide library
Prof. Linda C. Beaumont –
Very clean product with confirmed 100% purity via HPLC. The noDAC version is ideal for acute dosing protocols where continuous activation isn’t desired. Shipping was fast and lyophilized cake was intact
Dr. Kevin T. Olson –
Solid product for growth hormone secretagogue research. No unexpected degradation peaks. The noDAC formulation is clearly distinguishable from CJC-1295 with DAC in our pharmacokinetic assays. Minor delay in tracking info, but product quality made up for it
Dr. Alistair J. Ng –
Excellent batch consistency. Compared to full DAC versions, this analog gave us the short half-life needed for pulsatile signaling experiments. Great value for research use. Will order again
Prof. Raquel M. Fuentes –
Flawless performance in both cell cultures and rodent models. The 100% purity claim held up under our mass spec analysis. One of the cleaner research peptides we’ve sourced this year.