Description
Kisspeptin-10 is a decapeptide, a chain of ten amino acids, sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, the shortest bioactive fragment of the kisspeptin-54 protein encoded by the KISS1 gene. The gene was first identified in 1996 at Pennsylvania State University, originally in cancer research as a metastasis-suppressor gene, molecular formula C63H83N17O14, molecular weight 1,302.45 g/mol, CAS 374675-21-5.
Kisspeptin’s research significance shifted substantially after its role in reproductive endocrinology was discovered: the KISS1 gene product was found to be the natural ligand for the GPR54 receptor (now called the kisspeptin receptor), and kisspeptin signaling was identified as the key upstream trigger for GnRH release from the hypothalamus, the hormone that governs the entire reproductive hormonal cascade (LH, FSH, and downstream sex hormone production). This discovery repositioned kisspeptin from a cancer-research curiosity into one of the most studied peptides in reproductive and fertility research, including work on puberty onset, fertility regulation, and hypothalamic hormone signaling.
The C-terminal amide group (-NH2) on the final phenylalanine residue is a defining structural feature, distinguishing Kisspeptin-10 from truncated variants lacking this modification. It is supplied as a white lyophilized powder, highly soluble in bacteriostatic water, purity 98% or higher by HPLC. This product is strictly for research purposes only.
PubChem Reference: View compound profile on NIH PubChem
This product is strictly for research purposes only. Not approved for human or animal use.
Key Characteristics
MOLECULAR PROFILE
Formula: C₆₃H₈₃N₁₇O₁₄
Weight: 1302.45 g/mol
CAS: 374675-21-5
Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
PHYSICAL PROPERTIES
Form: White lyophilized powder
Purity: ≥98% (HPLC)
Solubility: Highly soluble in bacteriostatic water
Storage: Keep refrigerated 36‑46 °F (2‑8 °C)
Kisspeptin-10 in Published Research
Kisspeptin-10 is widely used as a research tool for studying the hypothalamic-pituitary-gonadal (HPG) axis, since it directly triggers GnRH release, making it useful for probing reproductive hormone signaling without needing to work with the larger, less stable kisspeptin-54 parent molecule. Published research has explored its role in puberty timing, fertility and ovulation research, and as an investigational approach to reproductive hormone disorders, building on the foundational discovery of the KISS1/GPR54 signaling pathway.
Frequently Asked Questions :
What is Kisspeptin-10 studied for?
Reproductive endocrinology research, since it triggers GnRH release and sits upstream of the entire reproductive hormone cascade.
How is it related to fertility research?
Kisspeptin signaling is essential for puberty onset and ovulation, making Kisspeptin-10 a key tool for studying fertility and reproductive hormone regulation.
Why the “kisspeptin” name?
The KISS1 gene was named after Hershey’s Kisses chocolate, discovered at Penn State, located in Hershey, Pennsylvania.
How should it be reconstituted and stored?
Bacteriostatic water, refrigerate 2–8°C.
Where can I buy it?
5mg and 10mg kits, HPLC/MS verified.
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