TB-500

Formula C212H350N56O78S, Weight 4963.4 g/mol, CAS 77591-33-4, Structure: 43 amino acid peptide

Form: lyophilized powder. Solubility: water-soluble. Appearance: white to off-white powder. Storage: store in freezer for long term stability.

TB-500 and Thymosin Beta-4 in Published Research

The strongest evidence for Thymosin Beta-4’s role in tissue repair comes from animal studies and cell culture research. In rat models of full thickness skin wounds, researchers have reported meaningfully faster re-epithelialization, in some studies over 40 percent faster within the first several days compared to controls, along with improved wound contraction. Thymosin Beta-4 has also been studied for its effects on corneal repair, cardiac tissue after injury, and hematopoietic stem cell regulation through a related fragment called Ac-SDKP.

A smaller body of human research has examined the full length Thymosin Beta-4 molecule under names like RGN-259 for dry eye disease and RGN-137 for chronic wounds, with some studies showing accelerated healing in conditions such as venous stasis and pressure ulcers. It is important to note that TB-500, the short synthetic fragment sold as a research chemical, is not chemically identical to the full length molecule studied in these human trials, though it shares the same core actin binding region believed to drive much of the biological activity. Systemic use of TB-500 in humans has not been evaluated in completed randomized controlled trials.

Frequently Asked Questions :

What is TB-500 peptide used for in research?

TB-500 is studied primarily for its role in cell migration, angiogenesis, and tissue repair. Researchers use it as a model compound to investigate wound healing, soft tissue regeneration, and the actin binding mechanisms that drive cellular movement during injury response.

What benefits does TB-500 show in published studies?

Animal research has associated Thymosin Beta-4 and TB-500 with faster wound closure, improved collagen organization, new blood vessel formation, and reduced inflammatory signaling during tissue repair. Related human trials using the full length molecule have shown benefits in corneal and dermal wound healing, though systemic use of the TB-500 fragment specifically has not been evaluated in completed human trials.

What dosages of TB-500 are used in animal research?

Published rodent studies investigating wound healing have generally administered Thymosin Beta-4 in the low milligram per kilogram range, either topically or systemically, depending on the study design. These figures reflect published animal research protocols, not instructions for human use. Peptides Vital sells TB-500 strictly for laboratory research.

How should TB-500 be reconstituted and stored?

TB-500 is supplied as a lyophilized powder, typically reconstituted with bacteriostatic water for laboratory use. Once reconstituted, it should be kept refrigerated for short term use, while unreconstituted vials are best stored frozen for long term stability.

Where can I buy TB-500 peptide for research?

Peptides Vital supplies TB-500 in 5mg and 10mg kits, with every batch verified through HPLC and mass spectrometry testing. A certificate of analysis is available on request, and the product is sold strictly for laboratory and scientific research.