Description
GHK-Cu is a copper-binding tripeptide, glycine, histidine, and lysine bound to a copper(II) ion, molecular formula C14H21CuN6O4, molecular weight 404.9 g/mol, CAS 89030-95-5. First identified in 1973 by Loren Pickart during research on human plasma, where he observed that this small copper-peptide complex occurred at higher concentrations in younger blood samples than older ones.
The copper ion is coordinated to the peptide through the nitrogen atoms of the glycine and histidine residues, giving the compound its distinctive blue color in crystalline form, an unusual property among research peptides. GHK-Cu is classified as a metallopeptide, a peptide that incorporates a metal ion as part of its core structure, and occurs naturally in trace amounts in human plasma, saliva, and urine. This natural occurrence combined with the age-related decline Pickart originally observed is the basis for most of the compound’s research interest in tissue repair, collagen synthesis, and skin biology.
The compound is supplied as a blue crystalline powder, highly soluble in water, stored refrigerated at 2–8°C and protected from light. This product is strictly for research purposes only, and should only be handled by qualified researchers in appropriate laboratory settings.
PubChem Reference: View compound profile on NIH PubChem
This product is strictly for research purposes only. It is not approved for human or animal use and should only be handled by qualified researchers in appropriate laboratory settings.
Key Characteristics
MOLECULAR PROFILE
Formula: C14H21CuN6O4
Weight: 404.9 g/mol
CAS: 89030-95-5
Structure: Gly-His-Lys (with bound copper)
PHYSICAL PROPERTIES
Form: Blue crystalline powder (the blue color comes from the copper)
Solubility: Highly water-soluble
Natural Occurrence: Found in human plasma, saliva, and urine
Storage: Keep refrigerated 36–46 °F (2–8 °C), protect from light
GHK-Cu in Published Research
GHK-Cu has one of the longer research histories of any peptide in this category, spanning more than five decades since Pickart’s original 1973 observation. Published research has investigated its effects on collagen and elastin synthesis, matrix metalloproteinase (MMP) regulation involved in tissue remodeling, antioxidant activity, and hair follicle stimulation. Because of this collagen and remodeling research, it’s frequently studied both topically (in dermatology-adjacent research) and via injection, two very different delivery contexts worth distinguishing when reviewing the literature.
Frequently Asked Questions :
What is GHK-Cu studied for?
Collagen synthesis, tissue remodeling, antioxidant activity, and hair follicle research, building on its natural role in the body.
Injection vs. topical, does it matter?
Yes, most published GHK-Cu research separates these delivery routes, since bioavailability and effects differ substantially between topical and injectable use.
What benefits are reported in studies?
Research associates it with increased collagen/elastin production, MMP regulation, and hair growth-related effects, primarily from preclinical and dermatology-adjacent studies.
How should it be reconstituted and stored?
Bacteriostatic water, refrigerate 2–8°C, protect from light.
Where can I buy it?
50mg and 100mg kits, HPLC/MS verified.
Dr. Sofia L. Monteiro –
Truly remarkable batch-to-batch consistency. GHK-Cu from Peptides Vital outperformed two other major vendors in our collagen synthesis ELISA. Copper content was spot-on. A five-star product across every metric
Dr. Jasmine K. Thorne –
Best GHK-Cu we’ve used in five years. The 99% purity claim is honest our HPLC showed 99.3%. Minimal free copper contamination, which is a common issue with cheaper sources. This will be our exclusive supplier going forward
Prof. Anders E. Nordström –
Flawless every time. Matrix metalloproteinase inhibition assays gave textbook results. The price point ($33–$64) is excellent for this level of quality. Lyophilized powder reconstitutes immediately. Can’t recommend enough
Prof. Miguel R. Herrera –
Remarkable stability compared to other suppliers we’ve tested. GHK-Cu retained full bioactivity for weeks when stored properly. CAS 89030-95-5 verified. A true workhorse for our wound healing and anti-aging research models